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Cyclophosphamide
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Cyclophosphamide

Cyclophosphamide remains one of the most successful and widely utilized antineoplastic drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation (BMT). It was initially synthesized to selectively target cancer cells, although the hypothesized mechanism of tumor specificity (activation by cancer cell phosphamidases) transpired to be irrelevant to its activity. Nevertheless, Cyclophosphamide's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties. Differential cellular expression of aldehyde dehydrogenase has an effect on the anticancer therapeutic index and immunosuppressive properties of Cyclophosphamide. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of Cyclophosphamide in cancer and autoimmune disorders. We also discuss the development of high-dose Cyclophosphamide for BMT and the treatment of autoimmune diseases.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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The angular process of Monodelphis domestica (Didelphidae, Marsupialia) and its relation to the middle ear: an ontogenetic and evolutionary morphologic study According to the connectivity patterns, a dorsal/ventral sensory segregation of auditory and visual processing and the medial TGm involved in the olfactory processing were observed. The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins contains three vertebrate members (LRIG1, LRIG2 and LRIG3) and one member each in flies (Lambik) and worms (Sma-10). Similar conclusions were reached when assessing BP over time and when examining specific tumor subtypes.

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NF-YA overexpression typically led to severe growth retardation and developmental defects, which extended from embryogenesis through to adult plants. Few studies have associated microRNAs (miRNAs) with the hedgehog (Hh) pathway. In experimental data, we find that after taking uncertainty into account using bootstrapping techniques, the majority of neurons appears to be very stable on a timescale of minutes to hours. A 175 kDa Plasmodium falciparum erythrocyte binding antigen (EBA-175) binds sialic acid residues on glycophorin A during invasion of human erythrocytes. Exposure to multiple traumatic events, particularly in childhood, has been shown to result in more complex symptoms than those seen after exposure to a single traumatic event.

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Synergistic combination of clinical and imaging features predicts abnormal imaging patterns of pulmonary infections. This study assessed the safety and patient satisfaction with conversion from sildenafil to tadalafil. When a labelled cell suspension is prepared from a dorsal half-retina, more cells adhere to the ventral half of the tectum. Current evidence supports that DM is associated with increased risk for selected geriatric conditions.

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Intraoperative video footage demonstrates the feasibility and facility of this approach in patients with common cavity deformities. It is therefore possible to make dynamic real-time scans from the vitreous and retina at the posterior pole and in the peripheral retina. A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug.

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Long-term environmental light intensity is a major determinant of retinal gene and protein expression, and of visual cell survival following acute photooxidative insult. Effect of birth parameters on retinal vascular caliber: the Twins Eye Study in Tasmania.

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Accuracy of lead placement within the brain can affect the outcome of deep brain stimulation (DBS) surgery. Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells.

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These relationships warrant further investigation in a large prospective multicenter trial. Potential role of catalase in mice with lipopolysaccharide/D-galactosamine-induced fulminant liver injury. We report a case of a suspected supraclavicular lymph node relapse, diagnosed by PET-CT in a breast cancer patient. A label-free approach to shotgun analysis is a great tool for characterizing proteins in a biological system. Effect of PG0839 gene of Porphyromonas gingivalis on inflammatory cytokine in human oral epidermoid carcinoma KB cell

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Venorelbine and methotrexate for the treatment of Rosai-Dorfman disease. The relative body fat and anthropometric prediction of body density of South Australian females aged 17-35 years. On the other hand, this would give outer layer bubbles enough time to dissolve, and inner bubbles can undergo violent collapse and emit bright light. Impact of a dedicated syncope and falls facility for older adults on emergency beds. Development of a new measurement instrument, construct validation, and association with dieting success.

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Systemic and liver inflammation in the high-risk cluster is likely to predict diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty. The optimal treatment duration needed for maximal neuroprotection remains unknown. Over 90 such factors were found, including proteins and protein complexes associated with transcription, RNA posttranscriptional modifications, and DNA replication and repair. These observations are important as some patients with DGCR6 syndrome exhibit a T-cell deficiency and/or cardiac malformations.

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Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. Pre-operative Axillary Ultrasound-Guided Needle Sampling in Breast Cancer: Comparing the Sensitivity of Fine Needle Aspiration Cytology and Core Needle Biopsy. These channels can be stimulated by raising internal cGMP levels and are known for their importance in smooth muscle relaxation. Reply: Reevaluating the Diagnostic Threshold for Eucapnic Voluntary Hyperpnea Testing in Athletes. The effect of fibrin glue on the intensity of colonic anastomosis in the presence and absence of peritonitis: an experimental randomized controlled trial on rats.

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Comprehensive analysis of human cells motion under an irrotational AC electric field in an electro-microfluidic chip. Therefore, to address these questions, we report the development and distribution of CD3 and CD4 by immunocytochemistry and the age-related mRNA level of duck T cell markers (CD3 and CD4) and Toll-like receptors (TLR2, TLR3, TLR4 and TLR7) by real time quantitative PCR in duck lymphoid organs (thymus, bursa of Fabricius and spleen).

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They rarely originate in the spleen as a primary tumor, with only ten cases having been previously described. These observations draw some useful insights into the possible mechanisms by which biomolecules, in particular peptides and proteins, bind to quartz and other silica surfaces. Disease-free ovarian cancer patients report severe pain and fatigue over time: prospective quality of life assessment in a consecutive series. This experiment offers a possibility to find new applications of atomic absorption spectrophotometer. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders.

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QEEG studies evaluating both the spontaneous brain activity and brain signals under controlled experimental stimuli were examined. Integrating reductive and synthetic approaches in biology using man-made cell-like compartments. The study was conducted as an interview-based case study containing interviews with key persons at the governing level as well as medical doctors at the operating level. Furthermore, the metabolic syndrome is reaching epidemic proportions across the world.

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Investigation of thermodynamic parameters in the pyrolysis conversion of biomass and manure to biochars using thermogravimetric analysis. Unlike previous methods in which the guiding tracks are fixed on flat two-dimensional surfaces, the flexibility of glass wires in shape and size facilitates building in-vitro devices that have deformable tracks. Kidney transplantation is a feasible therapy, but significant limitations were existed, including shortage of donor organs and lack of funding. In contrast to earlier findings, it has been shown that every response is determined by only two features, namely, the mean activities of the early and the late response (dynamic and static response component). Education and work in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

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Some aspects of sensory properties of food that relate to food habits and associated problems of elderly consumers. However, little information exists about the clinical performance of CAD/CAM titanium ceramic single crowns. Performance of exercises on unstable surfaces is thought to increase muscle activation, however no research has investigated differences in TrA activation when stable or unstable surfaces are used. Bile acid sequestrants (BAS) reduce LDL-C, yet their clinical efficacy on CAD remains controversial. Polyamines are essential for several living processes in plants.

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This study aimed to develop a method for the quantification of TAC in small biopsy-sized samples of rat kidney and liver tissue, which could be applied to clinical biopsy samples from kidney transplant recipients. High-risk sexual behavior in adults with genotypically proven antiretroviral-resistant HIV infection. In this study the synergistic activity of the acid mixture included inside hydroxypropyl-gamma-cyclodextrin (HPGCD) was monitored using in vitro tests and in vivo skin cancer models. A new study has reported the long-term effectiveness and cost-effectiveness of the direct-acting antivirals telaprevir and boceprevir for the treatment of chronic hepatitis C.

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Interactions of antiestrogens with human breast cancer in long-term tissue culture. Expert care includes routine management as well as advanced troubleshooting. Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover study. This is demonstrated for the specified regions of the frontal and occipital lobes and for the anterior cingulate. Upper gastrointestinal bleeding is one of the most frequent complications after cardiac surgery and endoscopic treatment (ET) is often the first-choice procedure.

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Histochemical investigations of fat in nodes of lesions of the subcutaneous fatty tissue in 25 patients with spontaneous panniculitis were carried out. However, in contrast to systolic heart failure, there are little data to guide treatment decisions in HFpEF, and no therapies have been shown to improve outcome in these patients. Investigation of the mechanism of gelatin-induced in vitro red cell aggregation.

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Evaluation of femoral neck bone mineral density and radiographic hand and knee osteoarthritis in a Korean elderly population. On the other hand, should a person be denied a chance to become a parent. We have evaluated the consequence of inducing active immunity against purified recombinant human ZP3 (rec.hZP3) and human ZP3 peptides, using the marmoset monkey, Callithrix jacchus, as an animal model. However, the METH-induced conditioned locomotion was unaffected by the pretreatment with 7-NI. The aim of this study was to evaluate technical results and clinical outcomes in a single center of consecutive elderly patients with unruptured intracranial aneurysms treated with endovascular embolization.

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This study investigated the immunomodulatory and anti-tumor effects of Nigella glandulifera Freyn and Sint seeds (NGS) on Ehrlich ascites carcinoma in a mouse model. Amniotic fluid embolism (it can present without respiratory manifestations).

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