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Lamotrigin (Lamotrigine)
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Lamotrigine

Lamotrigin is a phenyltriazine compound and its mechanism of action is thought to stabilize neuronal membranes via blockade of voltage-sensitive sodium channels, which blocks the influx of sodium ions and thereby reduces excess glutamate release. It’s also available as generic drugs. Generic drugs usually cost less than brand-name versions. In some cases, they may not be available in every strength or form as the brand-name drugs. Lamotrigin may be used as part of a combination therapy. This means that you may need to take it with other medications.

Other names for this medication:
Lamotrigine, Lamictal, Daksol, Epitec, Flamus, Labileno, Lafigin, Lamal, Lambipol, Lamez, Lamictin, Lamidus, Lamirax, Lamitor, Lamitrin, Lamogine, Lamolep, Lamotrigin, Lamotrigina, Lamotrix, Lomarin, Meganox,

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This study aimed to investigate the impact of LAT1 on proliferation, migration, and invasion of KKU-M213 cells, the CCA cells derived from Thai patients with intrahepatic cholangiocarcinoma. Due to the importance of community structure in understanding network and a surge of interest aroused on community detectability, how to improve the community identification performance with pairwise prior information becomes a hot topic. Study on the effect of atomic bomb radiation on thyroid function. The purpose of this article is to provide such data, as well as to identify some of the individual, family, social life and community predictors of changes in drinking patterns over time.

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The Duke Cancer Network created an Internet-based platform for a multidisciplinary conference to enhance the care of patients with lung cancer. Clustering analysis based on MS protein profiles highlighted that hemolymph samples were grouped according to tick species. Oxygen consumption in aortic tissue from rabbits with diet-induced atherosclerosis. The possible mechanism of action of chloroquine on the CNS responsible for the phenomenon observed was discussed. Instantaneous hematocrit changes at the outflow were registered and stored in digital form with the red cells serving as the nondiffusible tracer in the resulting washout curves.

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The impact of undergoing screening was evaluated with a 9-item questionnaire, and impact on HRQL with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire C30, version 3.0. In summary, our results suggest that neuronal GCS expression modulates MBH insulin signaling and WAT function in fasted mice. Isotypic characterization of IgA paraproteins: association with other clinical and analytic data The carotid bodies of renal hypertensive rats (one kidney wrap model) were studied by light-microscopic and morphometric methods.

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Possible role of glutathione in cofactor regeneration of dopamine beta-hydroxylase. We report on the use of dynamic scale theory and fractal analyses in the study of distinct growth stages of layer-by-layer (LBL) films of poly(allylamine hydrochloride) (PAH) and a side-chain-substituted azobenzene copolymer (Ma-co-DR13). Photon correlation spectroscopy (PCS) was carried out on tears of non-wearers and CL wearers who used MPS or H2O2 solution. Taken together, these findings suggest that several frontal and parieto-temporal regions may support cognitive processes shared by diverse creativity tasks, and that some regions may be specialized for distinct types of processes.

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The AIC (Akaike information criterion) involved two simplified models which were implemented for further analysis and prediction. The CPSS and LAPSS had similar test characteristics, with each having only limited specificity. We conclude that the outreach service is able to provide a comparable level of care when the urban model is translated to a rural setting.

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Thus, this work demonstrates an extended applicability of the amorphous track structure concept and tests its limits with respect to its predictive power. Early coagulopathy resulted from brain injury rather than hypoperfusion. Regarding the gait disturbance reported in kl/kl mice, the present study examined the spinal cord of kl/kl mice, and revealed decreases in the number of large anterior horn cells (AHCs), the amount of cytoplasmic RNA, the number of ribosomes and rough endoplasmic reticulum (rER), and the activity of ribosomal (r) RNA gene transcription without significant loss of the total number of neurons in the ventral gray matter.

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The subsequent application of genomic techniques to our sample set, in a global collaboration, has led to the identification of three robustly verified risk loci for AAA in the LRP1, LDLR and SORT1 genes. In addition to their original AED treatment, the children were assigned to different ketogenic diets based on their age. Impact of COMT genotype on serotonin-1A receptor binding investigated with PET.

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amylovora cannot obtain sufficient arginine from apple and pear fruit tissues or from apple vegetative tissues, either at the beginning of the infection process or after the infection has progressed to an advanced state. All subjects were studied at rest and during continuous incremental (ramp) cycle ergometry exercise. Prey preferences of the snow leopard (Panthera uncia): regional diet specificity holds global significance for conservation. Microtubules and microfilaments participate in the inhibition of synaptosomal noradrenaline release by tetanus toxin. Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney failure by mechanisms that involve oxidative stress, inflammation, and apoptosis.

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A kiosk-based tailored injury assessment tool can be successfully integrated into a busy pediatric practice. Seed germination and seedling growth in MTBE-contaminated soil were markedly reduced in all test plants. An extended workshop was held in April 2009 in which further recommendations were made from an expert panel, using the 2008 symposium material as a base. MP and TH have similar efficacy in relieving pain and improving function. Clinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex.

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An overview of municipal solid waste management and landfill leachate treatment: Malaysia and Asian perspectives. The remaining 84 samples were used to validate miRs differentially expressed between tumoral and matched peritumoral specimens by quantitative polymerase chain reaction. Design and Comparative Study of O3/P2 Hybrid Structures for Room Temperature Sodium-Ion Batteries. These twitches were accompanied by electromyographic bursts and were attributed to contractions of the bulbospongiosus muscle. A unique software tool has been developed to assist dentists in the difficult task of diagnosing radiographs for proximal caries.

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Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. However, similar reductions in skin blood flow were found for the same change in toe skin temperature.

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Radiology reporting of adrenal incidentalomas - who requires further testing? Treatment of patients with coralloid nephrolithiasis complicated by chronic renal insufficiency In the MVD preparation, the development of tolerance to the morphine effect was observed as well, but none of the ginseng saponins affected it.

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Whereas loss of Shp1 does not significantly affect Glc7 protein levels or localization, it causes reduced binding of the activator protein Glc8 to Glc7. A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity. Estimates of influenza vaccine effectiveness in primary care in Scotland vary with clinical or laboratory endpoint and method--experience across the 2010/11 season. Diabetes mellitus and atrial fibrillation: perspectives on epidemiological and pathophysiological links.

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Amino acid sequences of three peptide fragments of the 146-kDa reduced polypeptide, ligand affinity and immunoaffinity chromatography of the native protein, and sensitivity to pharmacological inhibitors, identified the trypanocidal material as xanthine oxidase (EC 1.1.3.22). CHS15 promoter activity, evaluated by measurements of beta-D-glucuronidase (GUS) activity, revealed a tissue-specific pattern of expression similar to that reported for CHS genes in bean. Physical activity, as evaluated by both the accelerometer and the 7-day PAR, was associated with a more marked nocturnal BP dip and, accordingly, a lower SBP and diastolic BP sleep to wake ratio. In the absence of antiviral therapy, recurrent infection is the norm with subsequent graft hepatitis and impaired survival. The clinical course of UTI is similar whether patients are hospitalized after emergency department management or discharged to a home hospitalization program.

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Awareness of this life-threatening complication after stent insertion is therefore mandatory. Gene 239FB, transcribed extensively in fetal brain, was isolated from the chromosome 11p13 region associated with mental retardation component of the WAGR (Wilms tumor, aniridia, genitourinary anomalies, mental retardation) syndrome. The Notch3 NRR uses a highly conserved surface on the third LNR module to form a dimer in the crystal.

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Conservative versus aggressive treatment strategy with angiographic guidance alone in patients with intermediate coronary lesions: The SMART-CASE randomized, non-inferiority trial. The aim was to evaluate the outcome of Ahmed glaucoma valve (AGV) in post-penetrating-keratoplasty glaucoma (PKPG).

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HPV16-E2 protein modifies self-renewal and differentiation rate in progenitor cells of human immortalized keratinocytes. The hagfish GPH consists of two subunits, alpha and beta, which are synthesized and colocalized in the same cells of the adenohypophysis. Effect of recombinant human interleukin 2 in experimental murine coccidioidomycosis. Family interaction was more disturbed in asthma compared with both the diabetic and the healthy groups.

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The results obtained in the Caco-2 bi-directional transport experiments confirmed the validity of the assay, given that high and low permeability profiles were identified, and P-glycoprotein functionality was established. Obesity prevalence and recent trends were estimated in the total population and according to socio-demographic variables. This review focused on the guanidine alkaloids derived from marine sources and discussed the recent progress on their isolation, synthesis and biological activities, covering the literature from the year 2010 to the present. Here we demonstrate that CD133BMSCs are capable of forming ectopic HMEs.

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Visual evaluations of leg-length inequality and internal foot rotation were unreliable and are not valid for TMD diagnoses. This study aimed to retrospectively assess the safety and technique of using the external oblique musculocutaneous flap to cover large thoracic wall defects after radical excision of locally advanced sarcomas in 20 patients at a single institution. The essential amino acid (except tryptophan) content of colostrum and milk of the sow. Additionally, we demonstrated that prior exposure to environmental enrichment prevented effects of reserpine in animals tested in olfactory fear conditioning. PVA particles are associated with intense uterine necrosis and extensive arterial occlusion regardless of size.

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Interestingly, nearly half the vesicles at excitatory synapses, and a third at inhibitory synapses, could not be recruited for release even by sustained stimuli. However, despite a wealth of behavioral and anatomical data, understanding how cholinergic synapses modulate cortical function has been limited by the inability to selectively activate cholinergic axons. Niche overlap was observed to be lower among species of the youngest clade (ruficollis) and higher among species of older clades (ferruginosus). On physical examination, there were diffuse white, soft, corrugated plaques involving the buccal and labial mucosa, oral commissures, and floor of the mouth. Patients were randomized to standard therapy or dexmedetomidine infusion groups.

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Patients with type 1 diabetes mellitus (T1DM) are more prone to develop other auto-immune diseases, including coeliac disease (CD). Simultaneously, a significant decrease in a cell length in the central elongation zone under clinorotation was revealed.

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Recommended childhood immunization schedule--United States, January-December 1997. Admission Glycaemia and Acute Insulin Resistance in Heart Failure Complicating Acute Coronary Syndrome.

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Milk C-PTHrP but not PTHrP 1-72 levels correlated significantly with milk Ca concentrations. An independent association was found between theta/gamma ratio and alpha3/alpha2 power ratio. Measurements of oxygen tension in the blood in low-pressure chamber tests Regression models indicated that Memory for Faces Delayed predicted the amount of Self-Play, Equipment use alone, and Cooperative Play with peers on the playground. Recent advances in nanostructures derived from monolayer colloidal crystal (MCC) have made remarkable progress in enhancing the performance of GaN-based LEDs.

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The recent wave of expansion in the field of lipidomic research is mainly attributed to advances in analytical technologies, in particular, the development of new mass spectrometric and chromatographic tools for the characterization and quantification of the wide array of diverse lipid species in the cellular lipidome. Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system. It is widely accepted that conflict-related goals, skills, and strategies are linked. This study aimed to assess the incidence and potential predictors of PPT in women with treated hypothyroidism antedating pregnancy.

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Grading is fundamental for optimal prognostication and treatment, and additional biomarkers are needed to support the histopathological diagnosis. Using the Flory-Huggins lattice model, we investigate the threading-unthreading equilibrium in a solution of linear flexible polymer chains and molecular nanotubes formed by covalently bonding the ringlike molecules, such as cyclodextrins (CDs). Shoulder pain in primary care--part 2: predictors of clinical outcome to 12 months.

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The results on FFMA were confirmed in a validation cohort of 45 patients. Local immunosuppression induced by high viral load of human papillomavirus: characterization of cellular phenotypes producing interleukin-10 in cervical neoplastic lesions. The clinical examination revealed that his movements were clumsy and that he had disproportionally short limbs.

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In the evolutionary studies of proteins, the average effect of natural selection operating on amino acid mutations may be examined by comparing the numbers of synonymous (dS) and nonsynonymous (dN) substitutions that have accumulated during the same time period. Proximity to Industrial Food Animal Production and Asthma Exacerbations in Pennsylvania, 2005-2012. However, pay-for-performance measures may financially penalize centers based on complications. Blood levels of protein markers of inflammation and nutrition in the meningo-encephalitis phase of human African trypanosomiasis

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A significant proportion of hospitalized CKD patients have hepatitis C. Comparative aspects of the methods of diagnosis of soft tissue injuries in traumas of the talocrural articulation The objectives are to investigate the peculiarities of the ultrasound pulse propagation through human extra/intracranial media by mathematical simulation and to confirm the simulation results experimentally by proving the suitability of the ultrasonic time-of-flight measurement method for human intracranial media (IM) physiological non-invasive monitoring.

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Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK. There was a high degree of correlation between the indices within each of the three groups, indicating that a region with a small provision in one area of child health services would tend to have few resources in other areas also.

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Fetal acidemia was defined as a pH of less than 7.0 in umbilical artery. Receptor analysis of idiotype antibodies derived from MALT type B-cell lymphoma hybridomas. The value of arterial spin-labeled perfusion magnetic resonance imaging (ASL) in cerebral ischemia Selecting CD133 (prominin-1) multipotent stem cell marker, enriched stem cells were analyzed by MACS using CD133 antibodies conjugated with magnetic beads.

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Although more recent studies have shown estimates of between 100 and 200 species per individual, this has not yet been made clear in the literature. Dimedrol, but not cimetidine abolished the enhancement of spontaneous lymphocyte adhesion, while the adhesion inhibition was blocked by cimetidine, but not dimedrol. Univariate and bivariate statistics were performed using STATA statistical software. We tested the hypothesis that BRS is substantially reduced in patients with spontaneous intracerebral hemorrhage (ICH) and that BRS can predict treatment outcomes.

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Aggregation phenomena are central to such bioprocesses affecting the viability, proliferation and differentiation trajectory of stem cells but a quantitative framework is currently lacking. We discuss here recent findings on the mechanisms of sequestrant-mediated glucose lowering via an increase of splanchnic glucose utilization through entero-hepatic FXR signaling. Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters. Loss of function by blocking EPO function using a pharmacological approach markedly increases antitumor activity of anti-VEGF drugs through inhibition of tumor angiogenesis.

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Immunization also induced the synthesis of relatively large quantities of NTHI-directed antibodies which were detectable in both the bloodstream and the alveolar spaces of the lung. Understanding the epidemiology of these pathogens is imperative for the development and use of future vaccines and other preventative interventions. Available evidence suggests that centrally acting sympatholytic agents, beta-adrenoceptor antagonists (beta-blockers) and diuretics may have the potential to further impair sexual function. The patients in the computer-assisted surgery group had lower embolic loads compared with the patients in the conventional total knee arthroplasty group.

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Ultrasound scan of the left eye showed a large cystic mass in the orbit due to extension of ipsilateral frontal mucocoele. Adrenal corticosterone response to ether stress did not appear in male rats at 12 days of age, but a distinct response was observed in female ones at the same age. In contrast to animal and fungal cells, green plant cells contain one or multiple chloroplasts, the organelle(s) in which photosynthetic reactions take place.

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Sole reliance on echo-derived assessment of AS may at times be problematic. Application of enhanced CT in the differential diagnosis of peritonsillar abscess and intratonsillar abscess A role for CSF-1 in reproduction was originally suggested by the sex steroid hormone-regulated uterine epithelial synthesis of CSF-1 and the expression of its receptor in trophoblast and decidual cells. PACAP was a slightly more effective stimulator of LH release by pituitary cells from castrated than intact rats.

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Additionally, those boys whose parents supervise them closely are more fearful of criminal victimization, but have lower levels of perceived risk of victimization. We describe a manufacturable and scalable method for fabrication of multiscale wrinkled silica (SiO2) structures on shrink-wrap film to enhance fluorescence signals in DNA fluorescence microarrays. We have streamlined this process by introducing Ligation-Independent Cloning (LIC) capability to our intein expression plasmids, which provides a simple method for constructing self-cleaving tag-target gene fusions. Several parameters, such as the nature and the concentration of the CD, were studied and were found to have a significant effect on the enantiomeric resolution for all studied compounds. This article provides an overview of the background, clinical use, treatment outcomes, and safety of high-intensity focused ultrasound in the treatment of uterine fibroids and adenomyosis, including a summary of clinical trials comparing magnetic resonance- or ultrasound-guided high-intensity focused ultrasound with other minimally invasive or surgical interventions.

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Thus the selectins have generated much interest as targets for antiinflammatory agents. Dysregulation of serotonin signaling is reported to contribute to breast cancer pathophysiology by enhancing cell proliferation and promoting resistance to apoptosis. Beat-to-beat time series of heart rate, systolic blood pressure and respiratory phase were extracted and transformed into binary symbol sequences. In this study, a computer-based first-principles kinetic model is developed to predict the degradation mechanisms and fates of intermediates and byproducts produced during aqueous-phase advanced oxidation processes (AOPs) for various organic compounds.

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On the degree of contamination of the external environment by helminth eggs during therapy of helminthiases (experimental investigations) Identification of pure unknown powders was performed by comparing against a library of spectra containing biological agent surrogates and confusant materials, such as dusts, diesel soot, natural and artificial sweeteners, and drink powders, using linear correlation analysis. However, the effective treatment of SDB remains limited, and positive airway pressure therapy is still the mainstay of the treatment.

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Cases in which the timing for sentinel lymph node biopsy is controversial. Flexible access to conformationally-locked bicyclic morpholines. The contingent negative variation elicited following the informative warning signal was larger than that following the uninformative warning signal, and this effect was larger over the left hemisphere than over the right hemisphere. Activin A is a multifunctional cytokine essential for cell differentiation and apoptosis including genital herpes treatment acyclovir dose for children erythroid cell differentiation in the bone marrow.

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The Nav1.7 voltage-gated sodium channel, encoded by SCN9A, is critical for human pain perception yet the transcriptional and post-transcriptional mechanisms that regulate this gene are still incompletely understood. The studies using vascular endothelial growth factor (VEGF) for tumor angiogenesis imaging, annexin-V for imaging apoptosis and agents copegus 200 mg for hypoxia imaging are still in an early stage and the clinical role for these agents needs to be defined. A high index of suspicion of polymicrobial keratitis should be made in patients with multiple and systemic risk factors.

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The time course of the rate deceleration shown by these neurons during transition from postural rigidity to muscular atonia represents a mirror image of the rate acceleration which affects most of the pontine reticular neurons located in the gigantocellular tegmental field (FTG) during the induced cataplectic episodes. We review current evidence, expert recommendations, and compare professional society guidelines discussing the various diagnostic and management options for patients with pneumothorax to assist physicians and trainees involved in the care of hospitalized and outpatient adults who have primary, secondary, and traumatic iatrogenic pneumothorax. Awareness of varied presentations of darunavir drug rash ADHD and proper treatment of comorbid conditions is imperative in the comprehensive care of ADHD children. Mlvi-1, Mlvi-2 and Mlvi-3 represent three independent logi since there is no homology between them molecular clones that identify them and they map on different rat chromosomes.

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By introducing this minimally invasive dorsal surgical approach with neuronavigation in treating hypoglossal schwannoma, we believe that safe exposure and complete tumor resection can be achieved with minimal rate of morbidity. The 2-specimen Xpert strategy was most efficient in minimizing AII time while identifying all tuberculosis cases among individuals with presumptive tuberculosis in this low-burden setting. Presumably the expected decrease of CH2O was masked by the increased distal delivery of tubular fluid mainly due to an additional e coli uti bactrim breastfeeding effect of the diuretic on the proximal tubule. Experience during early postnatal development plays an important role in the refinement of specific neural connections in the brain.

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Dichlorofluorescein diacetate, monochlorobimane and calcein-AM were fluorophores for topiramate 50 mg enxaqueca em the measurement of the formation of reactive oxygen species (ROS), the quantification of glutathione and the membrane stability, respectively. This study investigates the effects of MnCl2 on PS metabolism in PC12 cells, relating them to those on cell apoptosis.