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Ciclofosfamida (Cyclophosphamide)
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Cyclophosphamide

Ciclofosfamida is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Ciclofosfamida to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Ciclofosfamida is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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However, the most salient feature of this fungus only became evident by a comparison of its stromatal HPLC profile, revealing several secondary metabolites that were hitherto not observed in stromata of any other member of the Xylariaceae. The clinical relevance of laparoscopy (LS) and laparoscopic echography (LSEG) in diagnosing and staging gastrointestinal carcinomas is assayed in the light of diagnostic methods in current use. Investigations into the blood plasma profiles of electrolytes, 17 beta-oestradiol and progesterone in sheep suffering from vaginal inversion and prolapse ante partum.

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Plant sterols and their role in combined use with statins for lipid lowering. Risks and benefits of long-term opioid use are poorly understood, particularly among older adults. This study sought to understand how local Somali Bantu refugee mothers perceive education or health needs of their children with disabilities.

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When, the previously reported MPSP type 7 is also considered from the same study area, Theileria orientalis types 1, 3 and 7 are observed in south India. Brief comment is made on the neurosurgical approaches currently in vogue. Our study suggests that small- and medium-sized practices may experience difficulty with the financial burden of PCMH recognition. The presence of diaphragmatic endometrial implants was confirmed at pathologic examination. Most articles were affiliated with North American research institutions, but there were also reports from Europe, Africa, South America, and Asia.

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I aimed to investigate the efficacy of group music therapy to reduce agitation in people with dementia. Routine chest x-ray study in diagnosis of myocardial dysfunction. We review the evidence supporting the utility of the interferon-gamma assay for the diagnosis of latent tuberculosis infection (LTBI) in low-prevalence countries.

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Genotype frequency dynamics is mainly determined by the elective migration (Rh locus) or the pathology (PGD locus). borealis over a period of at least 50 years, and that a similar strain elicits the same male-killing phenotype in a second Drosophila species, indicating that male-killing may be a stable long-term strategy.

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We have used the sensory nervous system of the Drosophila embryo to shed light on the mechanism by which Flamingo regulates axon growth. In conclusion, we are firmly convinced that a scrotal ultrasound should always be performed in the presence of acute scrotal pain. Anesthesia and post-operative care in surgery of aortic dissection--report of 28 cases Gold nanoshells-mediated bimodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light. Efficacy of lansoprazole against peptic ulcers induced by non-steroidal anti-inflammatory drugs: endoscopic evaluation of ulcer healing.

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The bipolar nature of the ICP8 filaments means that a second strand of ssDNA would be running through this filament in the opposite orientation, and this provides a potential mechanism for how ICP8 anneals complementary ssDNA into double-stranded DNA, where each strand runs in opposite directions. We suggest that hens are weakly motivated to reach the nest site during the searching phase. ECMO in neurosurgical settings has associated risks of intracranial hemorrhage and neurological compromise, while resource utilization is paramount given the high costs of this treatment.

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A review of the literature pertaining to immunohistochemical stains suggests the potential benefit of use of CD10, procollagen I, CD99, CD117, p63, and LN-2 in differentiating AFX from other spindle-cell tumors. The histology of CDB-4124-treated patients was generally inactive or atrophic, and less frequently, proliferative or secretory, superimposed upon which were novel changes including formation of cystically dilated glands, and secretory changes coexisting with mitoses and apoptotic bodies. To study the effects of methyltestosterone, isolated or associated to estrogens, on the bladder and urethra of castrated adult rats.

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Chlamydomonas reinhardtii is the most powerful photosynthetic eukaryotic unicellular model organism. In addition, recent cumulative evidence reveals their importance in immunological homeostasis.

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Pericentric inversions may have modified the morphology of the X chromosome of Eupsophus species. The present study was undertaken to define the effects of Trema guineense (Schum. Here we review several logistical issues that are integral to the development and delivery of SC therapy for cardiac disease. We speculate that this finding may be relevant to the development of brain and retinal injury.

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In one case vascular lesions were bilateral (case 3) and in two patients two different lesions coexisted in the same orbit (cases 1 and 2). This study aimed to investigate the characteristics of the descending projections from the CMA, associated with distinct patterns of RJMAs, to the thalamus, midbrain, pons and medulla in guinea pigs. Since platelets and thrombolysis were both inhibited in (J) and yet incidence of AMI is lower, OT would seem more important than LT as a determinant of overall thrombotic risk in this population. She is unusual because of her belief that she had had intercourse with the Devil, and because the belief was shared by her religious minister. vWF became markedly degraded during the anhepatic and reperfusion stages, as shown by the partial loss of high molecular weight multimers, the relative decrease of the intact 225 kD subunit and the increase of the native proteolytic fragments of 176 and 140 kD.

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Incidence of both procedures increased over the period, but diabetic patients had a larger increment compared with non-diabetic patients. Implementation of a multifaceted intervention resulted in an immediate and sustained decrease in the proportion of missed and refused doses of pharmacological thromboprophylaxis.

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Using these particles as antibody carriers in SERS-based immunoassays, broad dynamic range and low detection limits, and improved selectivity can be realized. Apoptosis plays a major role in several diseases, including viral infections, autoimmune diseases, cancer, cardiac infarct, and neurological disorders. IgG of R851 is able to block adhesion of dissociated cells swirled in suspension.

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Autonomic function associated with gastrointestinal motility and counterregulatory hormone secretion is another candidate which correlates with glucose variability. Olfactory bulb and sulcus aplasia were the most common findings in KS patients. There was no apparent stimulation in the activity of various phase II drug metabolizing enzymes following pentamidine treatment.

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A cross-section study was performed among 807 hypertensive patients in urban and rural community settings of Beijing in 2011. LDH, AP, GOT and GPT in blood serum of the tumour-bearing mice showed substantial alterations in the activity of these enzymes. An in-depth review of atrial myxoma is presented, examining the important clinical symptoms and diagnostic indicators. The resulting flow is consistent with the known circulation in the Bay. The quality of postoperative breathing is therefore as important as correction of the nasal deviation.

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We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. The carbohydrate counting method can be recommended as an additional tool in the nutritional treatment of diabetes, allowing patients with DM1 to have more flexible food choices. In order to understand how mutations in the NF1 gene impact brain structure it is essential to characterize in detail the brain structural abnormalities in patients with NF1. She developed intractable hypertension and a computed tomography scan showed coarctation of descending aorta with severe calcificaiton.

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A 49-year-old man with dilated cardiomyopathy and an ICD received eight unsuccessful shocks for a single episode of ventricular tachycardia after excessive alcohol intake and exercise. The Guidezilla extension catheter is an effective and safe tool that provides improved back-up support and increases the success rate of PCI for complex coronary lesion by radial access.

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Evaluation of the effect of home bleaching agents on surface microhardness of different glass-ionomer cements containing hydroxyapatite. The postoperative pain score in Group S was significantly lower than in Group G on days 1 and 2 after the septoplasty.

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Regarding the allelic effect on phenotype, in contrast to previous studies, we found that the type of PKD1 mutation, but not its position, correlated strongly with renal survival. It is scarcely discussed in the literature and is associated with adverse features.

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Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. Sperm count and sperm motility were decreased significantly by sodium valproate. Eleven animals were sacrificed at intervals from 15 to 120 minutes after balloon sphincteroplasty or sphincterotomy. The purpose of this study was to describe a hybrid technique for the removal of an eroded gastric band, as a safe and feasible option in patients with band erosions. A note on modeling pedestrian-injury severity in motor-vehicle crashes with the mixed logit model.

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Reduced thyroidal uptake of inorganic iodine in liver cirrhosis. Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation.

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The aim of this study was to assess the quality of referral of psychiatric patients to specialists in internal medicine. Colocalization of these molecules to the endoplasmic reticulum in cerebellar Purkinje cells indicates that they are organized into a complex in developing neurons. In this study, we investigated if PGK1 is a promising candidate in inducing stem cell differentiation in gastric cancer. Significant differences were found in all cortex regions, the caudate nucleus and putamen, the hippocampal formation, the cerebellar cortex, and the thalamus between the ischaemic groups (7- and 10-min groups) and the control group (0-min group). In addition, the testlet and bifactor models displayed superior fit indices over a unidimensional IRT model.

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Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposure. Both the preparation and the implementation of the project were extremely difficult and almost failed due to problems of transportation, of red tape, and of security. Age and concentration complaints were important independent predictors of long-lasting work disability, whereas no evidence emerged to indicate that the degree of manual labor (blue or white collar work) or educational level was involved in persistent work disability in postwhiplash syndrome. In vitro studies on inner cell masses isolated from normal and tail-short mutant mouse blastocysts. Several tumour subtypes overexpressed targets of directed therapies suggesting potential therapy leads.

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The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems. Speciation of organic phosphorus in a sediment profile of Lake Taihu. Directed self-assembly at the 10 nm scale by using capillary force-induced nanocohesion. Their antibacterial and antifungal activities were assessed on nine bacterial and four fungal strains.

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Survival and progression were assessed using the Kaplan-Meier method, and multivariate analysis was completed. The data of this study will serve as a guide for the ALT flap characteristics in Indian patients. Distally based sural artery flap is very useful in covering the defects of lower leg, heel and dorsum of foot. Prevalence and characterization of BRCA1 and BRCA2 germline mutations in Chinese women with familial breast cancer.

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In contrast, delta-9-tetrahydrocannabinol (THC), the primary psychoactive component in cannabis, is associated with acute and neurodevelopmental propsychotic side effects through its interaction with central cannabinoid type 1 receptors (CB1Rs). Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease. It should therefore be preferred when prophylactic or empirical antifungal therapy is introduced in cancer patients with neutropenia. All subjects underwent the upper lid sling procedure with modifications. Therapeutic strategies from various aspects are needed for cancer therapy.

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Standard and quantitative far-Western experiments showed a complex including p53, Notch-1, and MAML1. Therefore, we speculate that this new family of Ras/Rap1-specific endopeptidases (RRSPs) has potential to inactivate both wild-type and mutant Ras proteins expressed in malignancies. Well-conducted long-term studies are urgently needed to permit a meaningful assessment of the survival or success rates of ZI and a statement concerning their application as an alternative to TI. Clinical effects of Portulaca oleracea seeds on dyslipidemia in obese adolescents: a triple-blinded randomized controlled trial.

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HCoV-NL63 is prevalent in winter and is associated with younger age and with shorter fever duration. A meta-analysis on the effect of dietary application of exogenous fibrolytic enzymes on the performance of dairy cows. To date, five isoforms of NO synthase (NOS) and four subunits of soluble guanylyl cyclase have been cloned. We analyzed the impact of municipal areas socio-economic environment and trends in inequalities in smoking in Spain, 1987-2001.

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The aim of this study was to determine levels and distribution of the above mentioned compounds in liver samples of Caretta caretta and levels of porphyrins that have been proposed as sensitive biomarkers of exposure to contaminants. These included the development of novel, flower-based pollinator attraction mechanisms and the development of increased water transport capacity in stems and leaves. Treatment of Prader-Willi Syndrome consists of intensive rehabilitation, psychologicalcare, speech therapy and also, if patient is fulfilling appropriate criteria, growth hormone treatment. Lower levels of cleavage were evident at Arg14-Lys15 and Lys15-Gln16.

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Here we develop a quantum mechanical framework and apply first-principles calculations to study the energy distribution and scattering processes of HCs generated by SPPs in Au and Ag. This pilot study is part of a long-term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC-associated genetic loci.

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Quickview questions, selected to serve as mental health screening questions, were compared with the Minnesota Multiphasic Personality Inventory-2, a widely used forensic assessment measure. Free radical-scavenging activity of the ginsenoside Re-lysine mixture increased upon heat processing. These cross-sectional analyses gave results consistent with pain hypervigilance, mediating the relationship of pain catastrophic cognition and anxiety sensitivity with pain-related fear. Though the exact roles of MFG-E8 have not been fully elucidated in diseases. We developed a facile and inexpensive fluorimetric microplate assay for the quantitation of 2HG and performed an unbiased small-molecule screen in live cells to identify compounds capable of perturbing 2HG production.

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Nearly all actigraphic parameters strongly correlated with PSQI self-reported sleep quality of inpatients and outpatients. A highly sensitive optical detection methodology, plasmon-waveguide resonance spectroscopy, was employed, capable of measuring binding in real time and discriminating between ligand molecules, without requiring labeling protocols (fluorophores or radioisotopes). Results indicate that the majority of the psychiatric nurses in this study did not have the knowledge necessary to act as advocates with respect to the ADA. Another major field of interest has been malignancy of the genitourinary system.

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To better understand the clarithromycin 500 mg er tabs direct role of hepatocytes in the production of ketolated carotenoids in songbirds, we measured the carotenoid content of subcellular components of hepatocytes from wild male house finches (Haemorhous mexicanus) that were molting red, ketocarotenoid-containing feathers (e.g., 3-hydroxy-echinenone). These effects may be modulated by various lipids carried by the particles, including the type of fat (saturated or unsaturated or oxidised fat), micronutrients such as vitamins and carotenoids which have antioxidant properties, and orally administered lipophilic drugs. Quantum fluctuation theorems and generalized measurements during the force protocol. Our study demonstrates that cross-reactivity between frequently targeted autoantigens is an important aspect of human systemic autoimmune responses.

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Signaling networks in living systems are coordinated azithromycin for chlamydia and alcohol through subcellular compartmentalization and precise timing of activation. We show that, by using the existing 8 TeV LHC data set, such a search would cover the entire unconstrained region.

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The COSIRA trial seeks to assess whether a percutaneous reduction of the coronary sinus can improve the symptoms of refractory angina in patients with limited revascularization options. Interestingly, both in cultures from augmentin and zoloft drug interactions hematopoietic stem cells and primary cells obtained directly from bone marrow, we identified a subset of morphologically distinct megakaryocytes which co-express glycoprotein VI and leukocyte-associated immunoglobulin-like receptor-1.