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Cyclophosphamide remains one of the most successful and widely utilized antineoplastic drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation (BMT). It was initially synthesized to selectively target cancer cells, although the hypothesized mechanism of tumor specificity (activation by cancer cell phosphamidases) transpired to be irrelevant to its activity. Nevertheless, Cyclophosphamide's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties. Differential cellular expression of aldehyde dehydrogenase has an effect on the anticancer therapeutic index and immunosuppressive properties of Cyclophosphamide. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of Cyclophosphamide in cancer and autoimmune disorders. We also discuss the development of high-dose Cyclophosphamide for BMT and the treatment of autoimmune diseases.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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The angular process of Monodelphis domestica (Didelphidae, Marsupialia) and its relation to the middle ear: an ontogenetic and evolutionary morphologic study According to the connectivity patterns, a dorsal/ventral sensory segregation of auditory and visual processing and the medial TGm involved in the olfactory processing were observed. The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins contains three vertebrate members (LRIG1, LRIG2 and LRIG3) and one member each in flies (Lambik) and worms (Sma-10). Similar conclusions were reached when assessing BP over time and when examining specific tumor subtypes.

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NF-YA overexpression typically led to severe growth retardation and developmental defects, which extended from embryogenesis through to adult plants. Few studies have associated microRNAs (miRNAs) with the hedgehog (Hh) pathway. In experimental data, we find that after taking uncertainty into account using bootstrapping techniques, the majority of neurons appears to be very stable on a timescale of minutes to hours. A 175 kDa Plasmodium falciparum erythrocyte binding antigen (EBA-175) binds sialic acid residues on glycophorin A during invasion of human erythrocytes. Exposure to multiple traumatic events, particularly in childhood, has been shown to result in more complex symptoms than those seen after exposure to a single traumatic event.

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Synergistic combination of clinical and imaging features predicts abnormal imaging patterns of pulmonary infections. This study assessed the safety and patient satisfaction with conversion from sildenafil to tadalafil. When a labelled cell suspension is prepared from a dorsal half-retina, more cells adhere to the ventral half of the tectum. Current evidence supports that DM is associated with increased risk for selected geriatric conditions.

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Intraoperative video footage demonstrates the feasibility and facility of this approach in patients with common cavity deformities. It is therefore possible to make dynamic real-time scans from the vitreous and retina at the posterior pole and in the peripheral retina. A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug.

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Long-term environmental light intensity is a major determinant of retinal gene and protein expression, and of visual cell survival following acute photooxidative insult. Effect of birth parameters on retinal vascular caliber: the Twins Eye Study in Tasmania.

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Accuracy of lead placement within the brain can affect the outcome of deep brain stimulation (DBS) surgery. Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529. HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells.

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Effects of pemetrexed, gefitinib, and their combination on human colorectal cancer cells. Ten subjects with T2DM were randomized in a double-blind fashion to receive 3g resveratrol or placebo daily for 12 weeks.

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parasiticus, derived from a nitrate-nonutilizing, versicolorin A (VERA)-accumulating strain. Arriving at the future sooner rather than later is the motivation for the FDA-led MicroArray Quality Control (MAQC) project. The gerbil BWB should not be used as a valid test of anxiety in its current form.

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These relationships warrant further investigation in a large prospective multicenter trial. Potential role of catalase in mice with lipopolysaccharide/D-galactosamine-induced fulminant liver injury. We report a case of a suspected supraclavicular lymph node relapse, diagnosed by PET-CT in a breast cancer patient. A label-free approach to shotgun analysis is a great tool for characterizing proteins in a biological system. Effect of PG0839 gene of Porphyromonas gingivalis on inflammatory cytokine in human oral epidermoid carcinoma KB cell

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Venorelbine and methotrexate for the treatment of Rosai-Dorfman disease. The relative body fat and anthropometric prediction of body density of South Australian females aged 17-35 years. On the other hand, this would give outer layer bubbles enough time to dissolve, and inner bubbles can undergo violent collapse and emit bright light. Impact of a dedicated syncope and falls facility for older adults on emergency beds. Development of a new measurement instrument, construct validation, and association with dieting success.

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This study showed that sharing of the types of errors that had occurred was significantly associated with a reduction in drug administration errors. To address these concerns, students at the Southern Illinois University (SIU) School of Medicine participated in an elective to develop a model family violence curriculum encompassing child abuse, IPV, sexual assault, and elder abuse. SRS8 on the growth and phytoextraction potential of energy crops Ricinus communis and Helianthus annuus in artificially Ni contaminated soils.

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Village level feeding of young children in developing tropical regions, with especial reference to Buganda. Sequence type (ST) 283 serotype III-4 and its novel single locus variant ST491 were detected in fish from Southeast Asia and shared a 3-set genotype identical to that of an emerging ST283 clone associated with invasive disease of adult humans in Asia. A retrospective study of patients with electrical burns was conducted to choose criteria for initial dispatching and establish a treatment protocol for out patient management. Short tests with semantic memory content are sensitive to changes in dementia and MCI, but impairments on such tests may also be found in other diseases, e.g.

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Quality of HIV health care provided by nurse practitioners, physician assistants, and doctors. Using flow cytometry, we detected a significant decrease of cell viability after hydrogen peroxide-induced oxidative stress in chicken pinealocytes. cABC treatment also enhanced axonal sprouting, but OPC migration occurs along a different time course and appears independent of new process outgrowth. The cells then phagocytoze the Con A and large phagocytic vacuoles containing it are observed.

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Systemic and liver inflammation in the high-risk cluster is likely to predict diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty. The optimal treatment duration needed for maximal neuroprotection remains unknown. Over 90 such factors were found, including proteins and protein complexes associated with transcription, RNA posttranscriptional modifications, and DNA replication and repair. These observations are important as some patients with DGCR6 syndrome exhibit a T-cell deficiency and/or cardiac malformations.

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Yellow rust is spreading by airborne spores potentially across long distances, which may contribute to sudden disease epidemics in new areas. To estimate the Prevalence of perinatal mortality and its associated risk factors. Statistically significant differences were noted univariately between types I, II, and III in regard to the development of an omental carpet, whether or not vaginal reconstruction was done, the performance of a perineal phase, the resection of additional tissues, and the duration of hospitalization.

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Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. Pre-operative Axillary Ultrasound-Guided Needle Sampling in Breast Cancer: Comparing the Sensitivity of Fine Needle Aspiration Cytology and Core Needle Biopsy. These channels can be stimulated by raising internal cGMP levels and are known for their importance in smooth muscle relaxation. Reply: Reevaluating the Diagnostic Threshold for Eucapnic Voluntary Hyperpnea Testing in Athletes. The effect of fibrin glue on the intensity of colonic anastomosis in the presence and absence of peritonitis: an experimental randomized controlled trial on rats.

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Comprehensive analysis of human cells motion under an irrotational AC electric field in an electro-microfluidic chip. Therefore, to address these questions, we report the development and distribution of CD3 and CD4 by immunocytochemistry and the age-related mRNA level of duck T cell markers (CD3 and CD4) and Toll-like receptors (TLR2, TLR3, TLR4 and TLR7) by real time quantitative PCR in duck lymphoid organs (thymus, bursa of Fabricius and spleen).

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They rarely originate in the spleen as a primary tumor, with only ten cases having been previously described. These observations draw some useful insights into the possible mechanisms by which biomolecules, in particular peptides and proteins, bind to quartz and other silica surfaces. Disease-free ovarian cancer patients report severe pain and fatigue over time: prospective quality of life assessment in a consecutive series. This experiment offers a possibility to find new applications of atomic absorption spectrophotometer. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders.

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QEEG studies evaluating both the spontaneous brain activity and brain signals under controlled experimental stimuli were examined. Integrating reductive and synthetic approaches in biology using man-made cell-like compartments. The study was conducted as an interview-based case study containing interviews with key persons at the governing level as well as medical doctors at the operating level. Furthermore, the metabolic syndrome is reaching epidemic proportions across the world.

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Investigation of thermodynamic parameters in the pyrolysis conversion of biomass and manure to biochars using thermogravimetric analysis. Unlike previous methods in which the guiding tracks are fixed on flat two-dimensional surfaces, the flexibility of glass wires in shape and size facilitates building in-vitro devices that have deformable tracks. Kidney transplantation is a feasible therapy, but significant limitations were existed, including shortage of donor organs and lack of funding. In contrast to earlier findings, it has been shown that every response is determined by only two features, namely, the mean activities of the early and the late response (dynamic and static response component). Education and work in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil

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Interactions of antiestrogens with human breast cancer in long-term tissue culture. Expert care includes routine management as well as advanced troubleshooting. Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover study. This is demonstrated for the specified regions of the frontal and occipital lobes and for the anterior cingulate. Upper gastrointestinal bleeding is one of the most frequent complications after cardiac surgery and endoscopic treatment (ET) is often the first-choice procedure.

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Effect of the conditions of premultiplication and selective multiplication of bacteria on the effectiveness of isolation of Salmonella in food This was a single-centre, prospective study conducted at an academic paediatric medical centre. Six weeks after ISO injection, the cardiac functions of lansoprazole 15 mg colombiancupid model group were damaged markedly compared with those of normal group. We compared these cases with 15 aortic root replacements performed using a BVC during the same period.

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Acute exacerbation (AE) of chronic hepatitis B virus (HBV) infection is common and negatively impacts the clinical outcome. We evaluated the prognostic factors of ipsilateral pm after cluvax forte surgical treatment, and validity of the new classification.

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