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Depsonil (Imipramine)

Depsonil, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Depsonil does not affect mood or arousal, but may cause sedation. In depressed individuals, Depsonil exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Depsonil and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Depsonil has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Depsonil may be used to treat depression and nocturnal enuresis in children. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD).

Other names for this medication:
Imipramine, Tofranil, Antidep, Depramine, Depranil, Deprinol, Depsonil, Imidol, Imipramina, Impril, Janimine, Melipramin, Talpramin, Tolerade,

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The immunogenicity of concomitantly administered Hib and DTwP vaccines was also diminished. Recent advances in biotechnology accelerated progress in the pharmaceutical applications of mAbs. The validation includes the establishment of analytical performance characteristics such as accuracy, reproducibility, precision and sensitivity. The present study suggests that Phx-3 might be a potential anti-metastatic agent as well as an anticancer agent.

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Non-surgical endoscopic trans-papillary treatment of ruptured echinococcus liver cyst obstructing the biliary tree. Here, we describe methods for constructing TALEN vectors that have been shown to achieve high success rates and mutation efficiencies in zebrafish. n., a new troglobitic spider species from south-west Europe (Araneae, Nesticidae). This study was an assessment of the professionalism curriculum at a community-based medical school from the perspective of undergraduate medical students. This paper describes a unique field dataset from weighing lysimeters beneath nonvegetated and vegetated systems that unequivocally demonstrates the role of vegetation dynamics in controlling water cycle response to interannual climate variability related to El Nino southern oscillation in the Mojave Desert.

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Evidence for the existence of a pristanoyl-CoA oxidase gene in man. Delocalization of nucleolar poly(ADP-ribose) polymerase-1 to the nucleoplasm and its novel link to cellular sensitivity to DNA damage. They also compared the performance of two defined subgroups of subjects with SDDs on expression analysis: one with normal and one with impaired recognition of facial identity. Treatment of herpes zoster ophthalmicus with corticotropin and corticosteroids.

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High blood levels of chromogranin A in giant cell arteritis identify patients refractory to corticosteroid treatment. To evaluate prospectively 3 different approaches to the management of a flat anterior chamber (FAC) because of overfiltration in the early postoperative period after trabeculectomy. The ACC N-malonyltransferase purified from this monoclonal antibody column has a molecular mass of 40 kD, which is cipmox 500 side effects different from that reported previously. Stavudine entrapped lipid nanoparticles for targeting lymphatic HIV reservoirs. High- and low-affinity NO3- uptake was reduced in an N-dependent manner in response to a rapid and large shift in carbohydrate remobilization triggered by defoliation.

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