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Genoxal (Cyclophosphamide)

Genoxal is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Genoxal to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Genoxal is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and investigated. The mRNA and protein levels of P16 were significantly reduced in radiation-induced thymic lymphoma tissue samples. AMERICAN Physiological Society, Sixty-fourth Annual Meeting, New York City, April 14-18, 1952. We also discuss the global asymptotical stability of the endemic equilibrium by autonomous convergence theorem. It is a fundamental aspect of constitutive eukaryotic gene expression and an important level at which gene expression is regulated.

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Correlations between various personality factors and contingent negative variation (preliminary note) COPD is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal breathing.

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7 days later, post-therapy whole body scan (pWBS) demonstrated thyroid remnant and showed a large area of abnormal radioiodine uptake located in the posterior left upper abdomen. Differentially-expressed genes (DEGs) between the habit and non-habit groups were identified using the Linear Models for Microarray Data software package. Repeat radiotherapy for recurrent breast cancer with total radiation doses of 60 Gy and the addition of hyperthermia in the majority of patients was feasible, with acceptable late morbidity and improved prognosis, particularly in patients with previous resection of recurrent tumours. Vertebral compression fracture (VCF) is increasingly recognized as an adverse event after spine stereotactic body radiotherapy (SBRT).

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These culture systems are also useful for directly testing the effect of compounds that may either inhibit or promote microglial activation. In the most severely affected patients the mortality for congestive heart failure exceeds that of many cancers. Tutoplast fascia lata and AlloDerm were also stronger than cadaveric fascia lata and DuraDerm, respectively. A total of 19 subjects were included between 1 January 2012 and 30 June 2015.

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The lethal action of ultraviolet rays has been studied on colored 4Crt, 4Lcp, 6Crt, 7Crt and white 4W, 4W1, 7Y, 7W2, 7W6 mutants of S. Decoy oligodeoxynucleotides bearing consensus transcription factor binding sites were introduced into chondrocytes to determine the functionality of our results. These findings are important in providing care to patients with HF in limited access settings but should be studied for longer periods in more heterogeneous populations.

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Self-medication with over the counter (OTC) and non OTC drugs may provoke serious consequences for users and societies. Experimental results on the benchmark of Cryo-EM images show that our method can improve the accuracy and processing speed of particle selection significantly. Ninety-seven laypersons examined VH patients exhibiting low back pain related body postures whose demographic cues varied by VH sex and VH race.

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Preference in the process of parturition: a comparison between primiparous and nulliparous women West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier. Gender or symptoms of oppositional defiant disorder (ODD) or conduct disorder (CD) did not moderate these findings.

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Comparison of leukocyte IL6 expression in patients with gestational diabetes mellitus (GDM) diagnosed by the Polish Diabetes Association (PDA) 2011 and 2014 criteria. Heterogeneous Hadean hafnium: evidence of continental crust at 4.4 to 4.5 ga. Combination therapy consists in the simultaneous administration of a conventional chemotherapy drug (or sometimes, a radiotherapy protocol) together with one or more natural bioactives (usually from plant or fungal origin) of small molecular weight. New designs in montages and analysis techniques have made the procedure practical. In order to exclude possible artifacts due to experimental design, we evaluated the possibility of a shift in preference when rats are conditioned either on their non-preferred side or on a randomly assigned side of conditioning.

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TENS and placebo TENS were worn throughout the rehabilitation sessions as well as during daily activities for those groups on the involved leg. Our results unequivocally demonstrate that local riverside populations will maximize the selenium health benefits of eating fish while minimizing their risk of being chronically exposed to mercury by preferentially consuming herbivorous species and to some extent omnivorous species, while avoiding piscivorous species.

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Combination of CP-31398 and TRAIL or chemotherapeutic agents enhanced cancer cell killing effect possibly through upregulation of p53-regulated genes such as KILLER/DR5. Herein, we outline the DMH protocol and illustrate its utility and the validation approaches used in analyzing the hypermethylation profile of breast tumor and normal samples. Radiological displacement occurred in both type B and C injuries but the clinical outcome was not correlated to this displacement.

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Despite improvements in hepatitis B surface antigen (HBsAg) test sensitivity, post-transfusion hepatitis B virus (HBV) infection still occurs because HBsAg is undetectable during the early window phase (WP) of the infection, in the convalescence core window phase of the infection, or in serologically silent chronic hepatitis or in mutant forms of HBV. Although further research on fertilization rate among these species is required to determine if there are reproductive barriers, the low level of genetic diversification in this genus hints that some ecological differences among acroporid corals play a role in the evolution of scleractinian corals, considering that the other members of this family, Acropora and Montipora, are highly diversified. VDR gene polymorphisms ApaI, TaqI, BsmI and FokI were typed by RFLP for 128 RA patients, 30 postmenopausal osteoporotic females and 150 healthy controls.

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We further discuss the competition between crystalline and amorphous regions and its influence on crystallization behaviors, such as the formation of double lamellae, chain tilt, the anomalies and adjacent re-entry. Comparative advantage strategy for rapid pollution mitigation in China. Serological diagnosis by immunofluorescence in experimental trichinellosis and leishmaniasis. Mitochondria and endoplasmic reticulum: mitochondria-endoplasmic reticulum interplay in type 2 diabetes pathophysiology.

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To investigate the differences in gene expression between N-type LA1-55N and S-type LA1-5S cells of the human neuroblastoma cell line LA-N-1, we constructed a subtractive cDNA library from LA1-5S cells. T2 quantification is commonly performed by applying an exponential fit to these two images, despite recent evidence that an exponential fit is insufficient to correctly quantify T2 in the presence of imperfect RF refocusing due to standard 2D slice selection or use of reduced refocusing angles.

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ABO blood grouping from hard and soft tissues of teeth by modified absorption-elution technique. Plasma microRNA192 in combination with serum CA19-9 as non-invasive prognostic biomarker in periampullary carcinoma. The purpose of this study was to provide updated and more comprehensive data on the correlates and patterns of acupuncture use in the United States, applying a sociobehavioral wellness model of utilization. Both low and high vitamin D concentrations were associated with increased risk of prostate cancer, and more strongly for high-grade disease.

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