Otarex is a first generation antihistamine that crosses the blood/brain barrier extensively and has a high affinity for histaminic receptors into the brain, thereby producing sedative- anxiolytic effects. Antihistaminic and bronchodilator activities have been demonstrated experimentally and confirmed clinically. Pharmacological and clinical studies indicate that Otarex at therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity. Wheal and flare reduction have been demonstrated in adult healthy volunteers and in children after intradermal injections of histamine or antigens. Otarex has also revealed its efficacy in relieving pruritus in various forms of urticaria, eczema and dermatitis.
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