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Topamac (Topiramate)

Topamac is a broad spectrum, antiepileptic drug used for various types of seizures, Lennox-Gastaut syndrome (a type of childhood onset epilepsy), and migraine prophylaxis. Topamac blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid (GABA) activity at some of the GABA receptors, and inhibits potentiation of the glutamate receptor and carbonic anhydrase enzyme, which all contribute to its antiepileptic and antimigraine efficacy.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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This substantiates further the notion that intralacustrine allopatric divergence may help to explain the high level of species richness of the mbuna in comparison to other Malawian cichlids, as well as of the Malawian haplochromines as a whole. This modification was used in a fracture of the scapular body associated with dislocation of the AC joint. We review the literature on the pathogenesis, clinical features, and treatment of postradiation acne, and discuss rapid resolution of a radiation-induced acneform eruption after combination treatment with tretinoin and minocycline.

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In this study, an integrated approach has been used in a selected population of adults with autism spectrum disorder to analyse both cerebellar morphometry and functional connectivity. The effect of catecholamines and beta-anti-adrenergic drugs on isolated short-circuited skin of the frog. Evolution of cyclophilin A and TRIMCyp retrotransposition in New World primates.

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Geometric asymmetry produced systematically increasing discrepancy between the equivalent hydrodynamic radius of translation and rotation-tabulated in this paper. Pattern distribution reflected the spectrum of presenting symptoms with more tower, interrupted and staccato patterns in children with daytime wetting than in those with monosymptomatic enuresis. OX(1)R-containing neurons were found throughout the nucleus, but were concentrated in its posterior region.

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Anesthesia and ventilation strategies in children with asthma: part I - preoperative assessment. These lines of evidence suggest that expression of the two storage-protein genes is independently regulated, and that the alpha/beta-gliadin genes possess novel regulation systems in addition to the prolamin box. Small resting B lymphocytes were highly enriched and completely depleted of all preactivated large B lymphocytes using countercurrent centrifugal elutriation and free flow electrophoresis. Detection of lipoarabinomannan-IgG in serum for the diagnosis of pulmonary tuberculosis

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We aimed to analyze the differential gene expression in various murine dental tissues, expecting to find novel factors that are involved in tooth formation. The mechanisms that integrate gene-regulatory processes with meiotic programs during reproductive development remain poorly characterized. The two isozymes appear to be active only as oligomers, and the potential physiological implications of this result are discussed. Anxiety Disorders and Obsessive-Compulsive Disorder in Individuals with Autism Spectrum Disorder. Ultrasonic source velocity distributions can be manipulated to provide beam shaping, as demonstrated by much previous work on focussing, side-lobe reduction and the production of Gaussian beam profiles.

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The histological features of human myocardium at different times after transmyocardial laser therapy have not been previously described. Concern has been raised that this is not suitable in the elderly.

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Geographic variation in oral health is marked at both the local and national levels. This study aims to assess changes in the left atrial and pulmonary venous anatomy due to respiration and to evaluate their implication for EAM acquisition.

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The significance of these findings for the understanding of the mechanisms of two types of D-E center function during fibrin clotting is discussed. Coronal reconstruction CT was used to measure the vertebral translation. Our choice of patient-relevant outcome measures will hopefully provide new knowledge on the potential for clinical improvements after performing comprehensive medication reviews in home-dwelling elderly people receiving polypharmacy.

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Live symposium presentation based on clinical practice and research, medical literature, and studies published between January 1998 and April 2009 on managing diabetes in older adults, government statistics, and medical society guidelines. The results of Fe, Cu, Zn and Cr were positively correlated between Dig. Fluorescence in situ hybridization (FISH) can detect a number of recurrent anomalies, and commercially available kits for melanoma detection have been devised. Investigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytes. The parents and offspring were independently interviewed with a modified version of the Schedule for Affective Disorders and Schizophrenia-Lifetime (Mannuzza et al., 1986) and completed a battery of instruments which included the Dimensions of Temperament Survey (Lerner et al., 1982).

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The relationship between earlier HHV6 infection and later CMV infection in pediatric patients with HSCT need further study. Identification of factors that impact recurrence in patients with borderline ovarian tumors. The results were superimposed on a cylindrical projection of an RNA double helix and the protection effects were shown to cluster at two regions on the molecular surface. This combined separation and detection scheme was applied to the direct analysis of these analytes and other interfering chemicals including uric and ascorbic acids in urine samples without off-line sample treatment or preconcentration.

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Influence of endotracheal tube diameter on forced deflation flow-volume curves in rhesus monkeys. Input and output channels are the DICOM Storage service, DICOM compact disks-read-only memory (CD-ROMs), and the local file system. oryzae mutant library consisting of over 70,000 ATMT transformants and for identifying genes -disrupted by T-DNA in the mutants by TAIL-PCR.

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Further development may lead to the design of an anticancer therapy based on the orally delivered immune checkpoint inhibition. This was consistently found both between trials (starting with or without upper body exercise) as well as within trials, when upper body exercise was started or stopped during the trial. The last 10 years have seen a great increase in isolation and identification of the large number of saponins present in blue cohosh. Elective surgery in hypertensive patients--preoperative considerations. Some studies have shown that serum resistin levels increase in hypertensive patients.

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Emergency medicine for the practitioner: coma and confusional states These results demonstrate that while both embryonic cortical and spinal cord NSCs have similar self-renewal properties and multipotency, they retain aspects of regional identity, even when passaged long-term in vitro. The association between the organ transplant and PCM is rare and, in unusual clinical presentations, the diagnosis difficulty may compromise a successful treatment.

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d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. However, little is known whether the nasal exposure to SE affects the development of allergic rhinitis (AR).

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Extended-spectrum beta-lactamases (ESBLs) derived from the TEM-1 beta-lactamase were first identified in the USA in outbreak strains of Klebsiella pneumoniae in the middle to late 1980s, together with the SHV-5 ESBL. The methanolic extracts of Hymenocardia acida root and trunk bark have vasorelaxant activity. In this context, theoretical studies can be helpful, and as such, computational spectroscopy is rapidly evolving from a highly specialized research field toward a versatile and widespread tool. Affected children are conceptually at risk for fractures and osteoporosis.

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During the healing phase, repair by substitution (e.g., fibrosis and scarring) or by proliferation of uninfected replacement cells may dominate sites of viral infection.(ABSTRACT TRUNCATED AT 250 WORDS) Differential effects of combinations of phospholipase A2 and phospholipase C on the activity of rat epididymal nuclear and microsomal 4-ene steroid 5 alpha-reductase. The conformations, secondary structures, compactness and hydrogen bonding of bursopentin were compared to its epimers using molecular dynamics simulations and first principles quantum chemical computations. Phylogenomic analysis showed multiple groupings of the species that could partly be associated with their ecological niches. Cellular membrane fluidity in amyloid precursor protein processing.

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This review focuses on our current interests in some of the genes and proteins involved in low temperature survival in insects. A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder. Expression levels of miR-31 in 126 pairs of bladder cancer and adjacent normal tissues were detected by real-time quantitative RT-PCR assay. To investigate whether basic laparoscopic skills acquired via structured spaced training on a box trainer persist after 6 months. Life changes related to the onset of juvenile rheumatoid arthritis.

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Information on demographic and clinical characteristics was collected. Receptor oligomerization: a pivotal mechanism for regulating chemokine function. The objective of this study was to determine the effect of neurotrophin-secreting Schwann cell implants on the urinary bladder after spinal cord contusion.

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Congenital granular cell tumor is a rare benign neoplastic growth affecting the gingival mucosa of neonates. Movable high-Q nanoresonators realized by semiconductor nanowires on a Si photonic crystal platform.

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Organic chemists and metabolic engineers use largely orthogonal technologies to access small molecules like pharmaceuticals and commodity chemicals. Complications such as pressure sores occur just as easily in children as in adults and the injuries tend to be just as intractable.

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The involvement of Psychodopygus yucumensis and Psychodopygus llanosmartinsi in the selvatic transmission cycle of Leishmania braziliensis braziliensis in a lowland subandean region. Doubling time of progression-free survival by palbociclib in metastatic breast cancer Distribution and bionomics of Egyptian Culex univittatus (Theobald).

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Therefore, these periodontal pathogens are not strictly related to periimplant disease sites. To observe the structural alterations of resistance vessels in spontaneously hypertensive rats (SHRs) and to evaluate the effects of captopril on them.

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Here we discuss the rates of the three main causes of increased drain outputs following robotic prostatectomy, as well as highlighting the resulting complications. This fate switch depends on loss of silencing of two PRC2 target genes, Cyclin E and the cyclin-dependent kinase inhibitor dacapo.

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Inhibitors of 5 alpha reductase (5 alpha R), the enzyme that converts testosterone to dihydrotestosterone (DHT), have been shown to retard the growth of hyperplastic prostates. The effect of hierarchical task representations on task selection in voluntary task switching.

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These findings suggest that the oscillatory mechanisms underlying attentional orienting to representations held in working memory are similar to those engaged when attention is oriented in the perceptual space. A de novo p.Arg756Cys mutation in ATP1A3 causes a distinct phenotype with prolonged weakness and encephalopathy triggered by fever.

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Further, Akita mice exhibited moderately increased SBP at 24 wks and increased sensitivity to PE-induced contractions in aorta and sympathetic nerve stimulation in CC at 12 and 24 wks. This article presents a general framework in which different manifestations of psychopathology can be conceptualized as dysfunctions in one or more mechanisms of self-regulation, defined as the ongoing process of managing personal goal pursuit in the face of internal, interpersonal, and environmental forces that would derail it.

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osloensis-caused-osteomyelitis in literature, occurring in a young healthy man. The size and morphology of the attachment points were similar for all ages. Its primary purpose is to confirm the importance of including a compounding pharmacist in the hospice care team, and it presents a short summary of how hospice began, its primary focus, the makeup of a hospice team, and suggested compounded treatments for common problems in hospice patients.

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The presence of hyperCKemia, proximal weakness, and myopathic EMG together were associated with highly positive diagnostic outcome of muscle biopsy. Interactions between hemisphere and handedness in the anterior cerebellum were due to a larger right-greater-than-left hemispheric asymmetry in right-handed (RH) compared to left-handed (LH) twins.

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Diffuse correlation spectroscopy (DCS) quantifies this decrease. Immediate side effects were only seen with antibodies specific for CD3 and CD8. The infarct size is limited, and left ventricular systolic function is preserved. Mental illness stigma among nurses in psychiatric wards of teaching hospitals in the north-west of Iran.

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Fixation of the posterior malleolus was made with anteroposterior screws in 20 patients using the PM approach and posteroanterior screws in 28 patients using the PL approach. Rubella antibody screening in a prenatal clinic using the indirect fluorescent method. Thus, Nup96(sim) and Nup160(sim) seem to be two components of the same incompatibility. Further work toward clinical application of these results is discussed. In this study, rhein was found to exert potent inhibitory effects against tumor necrosis factor (TNF)-alpha-induced human aortic smooth-muscle cells (HASMCs) proliferation.

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Sequence regions with profiles that are similar in the fragment and full-length transcript possess only base pairing partners within the fragment. Physicians need better understanding of modern methods of NFP to provide evidence-based contraceptive counselling to selected highly motivated patients who prefer NFP as a contraceptive choice.

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The use of this framework will lead to future studies targeted to determining the role of WSS in atherosclerotic plaque progression and vulnerability. Prolonged suppressive antibiotic therapy for prosthetic joint infection in the elderly: a national multicentre cohort study.

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The aim of this study was to investigate the difference in anxiety and quality of life (QOL) between mothers and fathers of children with anorectal malformations (ARM) or Hirschsprung disease (HD). Anterior segment ischaemia after excision of conjunctival squamous cell carcinoma.

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This paper presents a methodological approach for examining variation and consensus both within and between research settings and for addressing issues of generalizability and replicability. Maturation of outcomes of behavioral and electrophysiologic tests of central auditory function. Wildtype strain specificities are characterized by variations of the species-specific patterns. Alterations of B cell subset distribution have been described in the peripheral blood (PB) of rheumatoid arthritis (RA) patients, but no data are available on differences between the onset and the established phases of the disease.

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Measured capillary forces on spheres at particle-laden interfaces. Cooperation between the two heads of smooth muscle myosin is essential for full activation of the motor function by phosphorylation. The McRoberts maneuver and suprapubic pressure should be first-line treatment for shoulder dystocia. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. We analyzed operative data to investigate which factors were associated with outcomes and survival.

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Urinary tract infection (UTI) is one of the most common nosocomial infections, caused by Escherichia coli. The intravoxel incoherent motion perfusion parameters were derived by fitting the intravoxel incoherent motion biexponential model. Extract: The high price of many innovative drugs, which is in part due to the costs, time and risks involved in drug development, calls for more efficient approaches to bring drugs to the market. A modified procedure for assessing separate kidney function in chronic dog preparations with observations on the effect of chronic unilateral venous congestion.

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Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. This supports the practice of recommending any diet that a patient will adhere to in order to lose weight.

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Is a vaginal preparation of sildenafil citrate capable of alleviating acute menstrual pain in patients with primary dysmenorrhea (PD)? The final conclusion drawn from the results is that chair design differences had the greatest effect on seat pan interface pressure, followed by participant effects, and lastly postural treatments. No cytotoxic effect on HCjE cells was observed after EcN BGs inoculation for 30 and 120 minutes, as well as 24 hours. The clusters grew rapidly and became confluent in urban areas, lasting till week 22. Normal progression of genetic recombination requires timely degradation of many proteins, but little is known about the proteolytic mechanism.

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Accuracy of the lamellar body count in amniotic fluid contaminated by meconium. Tasks of Soviet public health in executing the resolutions of the 25th Congress of the CPSU The objective of this study was to quantify the blue-light hazards associated with glassware production. A new type of impregnated paper disc for determining microbial sensitivity to antibiotics and other chemotherapeutic agents.

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The potential of these processes as well as the influence of parameters such as coagulant or resin dose, pH or contact time were investigated for the treatment of two greywaters of low and high organic strengths. Early living-donor transplantation improves patient- and graft-survival compared with possible cadaveric renal transplantation (RTx), but the magnitude of the survival gain is unknown. Not significant statistical differences of these parameters were found between the cryotreated and untreated eyes. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.

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Serotonin concentration in the blood of patients with hemorrhagic fever with renal syndrome In this study, the whole mtDNA genome of Simao Chinese indigenous dog was amplified and sequenced. So it is necessarily to find some biomarkers associated with melanoma metastasis. Our study is the first to identify the early and late trichoscopic features of traction alopecia.

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The long-term effect of perspective change on the emotional intensity of autobiographical memories. In the antrum, patients from the Andean town had a higher prevalence of glandular lymphoid adherence lesions, active germinal centres, moderate to severe chronic atrophic gastritis, intestinal metaplasia and moderate to severe total deep gland loss, than did patients from the coastal town.

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There is ease of access to the anterior and posterior capsule, which can be resected under direct vision, thus permitting accurate hemostasis. MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. From its earliest days of ipproton 20 mg indications domestication, the domestic chicken (Gallus gallus domesticus) has been selectively bred for specific traits. Further research needs to be done to examine the role of leptin on metabolism, especially in ethnic groups predisposed to development of obesity and related disorders.

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The structures of the alkaloids magnoflorine, baptifoline, anagyrine, and N-methylcytisine have been known for many years. A total of 83 leftover specimens of 61 study participants who seroconverted were used in this sub-study. The metrovax tabletas 500 mg role of competition in word learning via referent selection. In many of these places access to dialysis and transplantation is limited, leaving few treatment options. We conclude that resveratrol can modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogenesis.

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Both dogs survived surgery and were alive 15 and 42 months, respectively, after surgery, however, 1 dog developed progressive mitral regurgitation after surgery. As evidence accrues for TAVR in high and intermediate risk patients, some clinicians advocate that muzica aurica jantoven generic all patients aged over 80 years should only receive TAVR.

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In this paper the results of calculations on the effectiveness of various monitoring strategies are gelnique dosing for benadryl presented for a sharp edge filter produced by three different physical vapor deposition methods. Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep.

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To investigate whether lateral bias is dependent on the number of stimuli presented, the present experiment employs a within-subjects design to present single spheres or pairs of spheres. The use of primers synthesized to eight class II restriction endonuclease target sequences, from Haemophilus parainfluenzae, Escherichia coli, Staphylococcus aureus, Salmonella infantis, Rhodobacter sphaeroides, Klebsiella pneumoniae, Bacillus amyloliquefaciens and Proteus vulgaris for single and multiplex PCR identification of the organisms is discussed. Potency ratios for local anesthetics in regional blocks: how long must we wait? This suggests that they can recognize a movement Gestalt when information about shape is minimal. However, little is known about the etiology of astigmatism or the amethopterin is the trade name for cefadroxil reason(s) for the association between spherical and astigmatic refractive errors.

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The median urinary excretion of 1,4-MIAA was 3.34 mg/24 h (range 1.47-4.66) in the patients with detrusor mastocytosis and 1.75 mg/24 h (range bandcamp nana grizol tabs 0.18-4.30) in the other patients with a painful bladder (P less than 0.01). Thus, aldosterone blockade with mineralocorticoid receptor antagonists offers target organ protection and may blunt some of the adverse effects of chronic high salt intake. 35 patients with clinically diagnosed TIA were prospectively included in our study. With this background knowledge, the present review focuses on the various EAMs of RA, their classification, clinical features, and general management overview. Carbon nanotube blended polyethersulfone membranes for fouling control in water treatment.

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Increased body surface temperature on low P:C diets was consistent with diet-induced thermogenesis (DIT) as a means to dissipate excess ingested energy on such diets, although this was not sufficient to prevent development of increased adiposity. Therefore, we employed a comprehensive set of paradigms (time discrimination, time estimation, time production, and time reproduction) in order paroxat 10 mg nebenwirkungen to explore the perceptual timing deficit profile in our ADHD sample.

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Recent sensory history plays a critical role in duration perception. We have sequenced distinct exons of the CREB binding protein (CREBBP) gene and analysed the output resulting from three major deep-sequencing platforms. Short-term and long-term effects of highly active antiretroviral therapy on the incidence of herpes zoster in HIV-infected children. Interactions of biosystems with low-frequency electric fields (theoretical secundum artem omeprazole magnesium aspect) Only outpatients were included and the presence of psychosis in previous episodes was not assessed.