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Topigen (Topiramate)

Topigen is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, Topigen was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults. Characteristics that distinguish Topigen from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.4 Interestingly, Topigen was discovered by chance when attempts were made to formulate a novel antidiabetic drug.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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It influences various phases of plant growth and developmental processes, such as seed germination, leaf and stem growth, and reproductive propagation. This article discusses the merits and limits of nonsteroidal antiinflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, for colorectal cancer prevention.

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However, we did not find an increased rate of recurrence due to needle-track seeding, and IGCNB remains our procedure of choice for diagnosing mammographically detected suspicious breast lesions. However, the bilateral sinus lifting prolongs the recovery time. The field segmentation approach was compared to an inverse planning system with a traditional beamlet-based beam intensity optimization. These changes may be the major reason for the diminished pathogenicity of TBEV strains.

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A cross-sectional study was conducted and 420 dental students were invited to participate. In a third group, a suspension of labeled cells was aliquoted onto the serosal surface of the uterus. Our aim was to develop a simulated objective assessment tool for a novice camera assistant. Kyphoplasty has been shown to provide symptomatic relief of vertebral compression fractures refractory to medical therapy. This study included 1702 girls and 1547 boys aged from 14 to 16 years from twelve gymnasium schools in Poznan (Poland).

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A large number of cell types have gastrin receptors including pancreatic cancer cells which have been shown to be stimulated by gastrin. HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Tracheal wire stent complications in malacia: implications of position and design.

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Sample preparation consists of placing a portion of dried, ground tobacco in a sample cup, and pressing at 25 tons pressure to make a compressed pellet. This is the first study demonstrating that PHA synthesis related to energy and carbon metabolism could be employed as a pathway to regulate other cellular metabolism and possibly to regulate the production of other metabolic products. Umbilical artery Doppler waveform notching: is it a marker for cord and placental abnormalities? A close relationship between patients, their caregivers, and all members of the transplant team is an essential component to successful lifetime management. These improvements are relevant for bias removal in long-range forecasts or predictions of climate indices based on percentile thresholds.

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The fatty acid composition, physicochemical and antioxidant as well as in vitro anticancer properties of extracted oil were studied to assess its suitability in food and therapeutic applications. Tocopherol protection from ultraviolet irradiation may have been due to both direct protection from free radicals and indirect protection by means of increased epidermal thickness.

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For IFNG and PTGS2, this study is a confirmation of their previously reported position. Other experiments showed that the degree of contraction at the time of fixation did not affect the presence of nexuses in the tissue. Many of the diseases discussed have overlapping presentations or may mimic more common noninfectious disease processes.

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A randomized, open-label study of the safety and tolerability of fospropofol for patients requiring intubation and mechanical ventilation in the intensive care unit. Local staining intensity was detected immunohistologically by the avidin-biotin-peroxidase method determining the highest dilution of anti-serum against bovine bone morphogenetic protein.

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Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte. Of all the subjects, 789 patients chose in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and 142 chose artificial insemination of donor (AID) or adoption.

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We show that when a truncated FGF receptor (XFD) was expressed ectopically in order to block FGF signaling Xslu expression was inhibited. Major health organizations have identified this issue as an urgent health problem for women, but the effects of these campaigns have rarely been tested with the target audience most affected by the issue. Characterization of the model system rice--Magnaporthe for the study of nonhost resistance in cereals. Overexpression of zfIRAK-4, zfTRAF6, or a mutant zfTLR3 construct was able to stimulate NF-kappaB activation in ZFL cells as measured by a cotransfected NF-kappaB-luciferase reporter plasmid.

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Experience in the use of prodigiozan in the treatment of chronic inflammatory diseases of the female reproductive organs The intracellular presence of MMP proteins was evaluated by western blot.

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Nonischemic cardiomyopathy substrate and ventricular tachycardia in the setting of coronary artery disease. These results encourage the development of models for preoperative estimation of costs related to perioperative morbidity. The observed effect of antidepressants may be of significance for their therapeutic effects in the stress-induced affective disorders in females. Glyceric acid kinase isolated from a Polish variety of rapeseed (Brassica campestris L.).

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Hypersomnolence and reduced activity in pan-leptin receptor knockout mice. Their gains in overall, motor, and cognitive functional status were measured with the use of the Functional Independence Measure (FIM). In a controlled clinical trial, 270 consecutively treated patients were allocated to three antibiotic groups, alternatively, according to order of participation in the trial: Group A (2 g amoxicillin single preoperative dose), Group B (single preoperative 2 g amoxicillin followed by 500 mg three times daily for 5 days) and Group C (postoperative amoxicillin with clavulanic acid 625 mg three times daily for 5 days). A total of 91 patients with PCOS and 53 age- and body mass index (BMI)-matched healthy controls were included in the study.

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During eukaryotic development, the induction of a lineage-specific transcription factor typically drives differentiation of multipotent progenitor cells, while repressing that of alternative lineages. An increase of cardio-vascular strain and psychobiological mechanisms may explain this decrease of endurance performance. There has been increasing interest in the use of complementary and alternative medicine (CAM) in the general population. This study evaluated minimal and moderate support versions of an Internet-based diabetes self-management program, compared to an enhanced usual care condition. Fraction 2 also induced the highest number of eosinophils and increased levels of interleukin 5 (IL-5) in the BAL fluid.

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tuberculosis oriC by DnaA occurs at precise location and is inhibited by IciA like protein. In this study, we evaluated the feasibility of using the Memory and Executive Screening (MES) for assessing cognitive performance in OSA. X rays (1 to 10 Gy) and 4-NQO (0.5 to 2.5 microM) induced ssDNA breaks to a similar extent in both human and rat testicular cells as measured by single cell get electrophoresis (SCGE) and alkaline filter elution.

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The aim of this review article is to derive a better understanding on the role of various micro-organisms in the etiogenesis of oral cancers through all the available data on the pubmed. This basic fact demonstrates the tight connection between ecology and evolution that defines the emerging field of eco-evolutionary dynamics.

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The mass drug administration programme to eliminate lymphatic filariasis with DEC in Kerala was started in 1997, extended to all the 11 endemic districts by 2005. Twenty-four rehabilitation patients with injured spines who were enrolled in a daily in-clinic program. Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis.

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Intracerebroventricular administration of PrRP in wild-type mice promoted hyperalgesia and reversed morphine-induced antinociception. The Cylex ImmuKnow (Cylex, Columbia, MD) cell function assay (CICFA) is a commercially available test of immune response that purportedly identifies solid organ transplant patients at risk for either acute rejection (AR) or infection. The application of the Ceriotti reaction to determination of deoxyribonucleotides. This paper reports on the sensitive, selective, and simultaneous detection of four protein biomarkers involved in metastasis of various cancers, namely Fas, angiopoietin-2 (Ang-2), human epidermal growth factor receptor 2 (HER2), and matrix metallopeptidase-9 (MMP-9) using an antibody-conjugated quantum dot (QD) chip and surface plasmon resonance imaging (SPRi) biosensors.

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Previous research has not shown any significant health gain for patients as a result of providing education about depression for GPs. The association of Coxsackie viruses with poliomyelitis and other human infections.

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The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Needling procedures or surgical revision, methods that are more invasive and potentially associated with severe complications, should be limited to the small percentage of eyes that do not respond to medical treatment.

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Furthermore highly sensitive PSA failure subsequently progressed to PSA failure in 3 cases. Edema spread to the epidermis, resulting in intercellular edema and subsequent dissociation of epidermal cells. The molecular organization of the gene cluster and proposed functions for the ML-236B biosynthetic genes in P. Post-term growth and cognitive development at 5 years of age in preterm children: Evidence from a prospective population-based cohort.

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CT cholangiography accurately depicts biliary tract anatomy in living donor candidates for right hepatic lobe transplantation, and donors who undergo preoperative CT cholangiography are unlikely to need conventional intraoperative cholangiography. Inhibition of antigen-antibody reaction on heterocorneal transplantation treated with urea

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The efficacy of US and MRI in screening for pancreatic lesions, including pancreatic cancer, was evaluated. Properly designed studies are needed to clarify the diagnostic performance of 68 Ga-PSMA PET/CT as well as its superiority over existing methods before 68 Ga-PSMA PET/CT can be routinely used for bone imaging.

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The exact pathogenesis of arthrogryposis is unknown, but all involve fetal akinesia (decreased fetal movement) with subsequent joint contractures. However, the mechanisms whereby the various classes of incretin-based therapies exert CV effects may be mechanistically distinct and may not necessarily lead to similar CV outcomes.

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The distribution of DSS, SAB, and AMY in liver tissue of the model rats was significantly decreased compared to the normal rats. Whereas studies in animals have shown prolactin to be an initiator and promoter of breast carcinoma, studies in humans have been inconclusive.

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Using Fresh and Frozen Testicular Sperm Samples in Couples Undergoing ICSI-MicroTESE Treatment. Kinetics of color development, pH decreasing, and anti-oxidative activity reduction of Maillard reaction in galactose/glycine model systems. Pathology-based validation of FDG PET segmentation tools for volume assessment of lymph node metastases from head and neck cancer. There was a significant improvement in cardiac and skeletal muscle bioenergetics that was maintained throughout the 47 months of therapy. Risk factors for Enterobius vermicularis infection in children in Gaozhou, Guangdong, China.

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Since polyethylene effectively transmits power without distorting the sound field of overheating in dog tests, it may now be used in Phase 1 clinical ultrasound hyperthermia tests on human patients. The malignant potential of this tumor remains unclear and was the object of our investigation.

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Researchers have developed a new type of medical micropump for an endoscopic robot, which is driven by a linear actuator based on a direct current (DC) motor. Treatment for suprachoroidal silicone oil migration following surgeries for open globe injuries. Specificity in steroid histochemistry, with special reference to the use of steroid solvents. Prospective, observational study of consecutive neonates requiring UVC insertion, in a tertiary care center, in an 18-month period.

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Retrospective study of patients with post-acupuncture pneumothorax evaluated in a tertiary hospital during a five-year period (2001-2006). These data suggest that 5-HTTLPR genotype moderates individual sensitivity to war zone stressors and the expression of emotional disturbance including PTSD symptoms. MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with antioxidant and anti-apoptotic functions. Submerged mandibular carious deciduous second molar along with an impacted second premolar associated with an atypical inflammatory follicular cyst: a rare case report.

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IL-1beta, IL-4, and IL-8, measured as total amounts (pg/30 s), were evaluated in 180 samples using a commercially available sandwich enzyme-linked immunosorbent assay. Foot position awareness in younger and older men: the influence of footwear sole properties. Here we further explored differences between the two types of measure by varying the proportions of trials with explicit hand-position (H) and cursor-position (C) judgments (C20:H80, C50:H50, and C80:H20). Survival analysis of the CEAwatch multicentre clustered randomized trial.

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Specifically, the microbeads were fabricated from alginate and collagen by barium ion cross-linking, with neonatal rat cardiomyocytes encapsulated in the composite microbeads during the fabrication of the EHT grafts. Based on meta-analysis of prospective studies, there is a weak but statistically significant nonlinear inverse association between fruit and vegetable intake and colorectal cancer risk.

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The critical factor in establishing the window of opportunity was the amount of time needed for fractional redistribution of a neuroparalytic quantum of toxin from the extraneuronal space to the intraneuronal space. We analyzed the results and reported the incidence of the problem. There is a rapidly growing awareness that plant peptide signalling molecules are numerous and varied and they are known to play fundamental roles in angiosperm plant growth and development.

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Superior turbinate tissue yields stem cells and immature neurons capable of differentiating into ORNs that retain many of their functional characteristics even after growth in culture. We review and compare the pharmacokinetic and clinical efficacy of lanreotide, the second SSA available in the market, in its different formulations.

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In this paper, we will discuss the strategies for the generation of cardiomyocytes from pluripotent stem cells and their characteristics, as well as highlight some applications for the cells. This relationship has now been confirmed by a range of studies that have revealed common structural features in their capsid proteins, and similar organizations and sequence conservation in their DNA packaging machinery and maturational proteases. A simple beside method for the determination of plasma salicylate. At a November 2012 workshop, state health policy officials, other Medicaid and insurance exchange practitioners, and health policy researchers discussed issues surrounding the implementation and sustainability of Medicaid expansion and insurance exchange coordination under the Patient Protection and Affordable Care Act (PPACA).

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EULAR/EFORT recommendations for the diagnosis and initial management of patients with acute or recent onset swelling of the knee. Topics covered include: Physical properties, management and planning of I-125, source logging, source transportation, source accounting during and after implant, room monitoring, recording, dosimetry films, nursing procedures, discharge of patient.

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Thereafter, postprandial serum non-esterified fatty acid (NEFA) and triacylglycerol (TAG) levels and fasting blood parameters were measured. Factors associated with hospitalization of adult psychiatric patients: cluster analysis. Hantaan virus (HTNV) is an Old World hantavirus associated with hemorrhagic fever with renal syndrome (HFRS). The spontaneous reaction of 1mM melphalan with 5mM GSH at sustiva missed dose of effexor 37 degrees C in aqueous phosphate buffer for 1h gave primarily the monoglutathionyl and diglutathionyl melphalan derivatives, with small amounts of mono- and dihydroxy melphalan derivatives.

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The prediction of the structure of technician (V) complexes using density-functional techniques. This study was a retrospective cohort analysis based on the ARNO database, a national record that tracks reimbursable prescription claims submitted from selected pharmacies to the Italian national health system. Based on vast experimental studies and many-years personal experience on the conservative and surgical terramycin ophthalmic ointment for pigs treatment of tuberculosis of the kidneys the author has made a conclusion of a necessary change of all the work for the detection and treatment of nephrotuberculosis.

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This article addresses the regulatory issues associated with the application of recent data to support Registration, Evaluation, Authorisation and Restriction of Chemical substances (REACH) requirements in Europe and the use of metal-specific parameters by other countries to generate remediation values for metals in soil. As parameters of efficacy the spontaneous pain and the pain caused by movements, the function and joint pain have been considered, while gastric tolerance has been evaluated by means of daily records made by patients and the general tolerance through an annotation of adverse events, vital signs as well as parameters of laboratory. JCHA (Joint Commission Commission on Accreditation of Hospitals) accreditation. Independent association of HbA(1c) and incident cardiovascular disease in people without diabetes. In this study, BALB/c mice depleted of AMs by intranasal instillation of dichloromethylene bisphosphonate (L-CL2MBP) liposomes were examined for disease, lung inflammation, and viral replication after infection with hMPV cifran tablet use for kids or RSV.

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Lysine 609 in the calmodulin autoinhibitory domain of bovine eNOS mediates aspirin-stimulated binding of eNOS to calmodulin and eNOS-derived NO production. Effect of nitrazepam, amylobarbitone sodium and placebo on the electroencephalogram of hirsutism treatment spironolactone dosage for high blood normal subjects. The surgical volumes of the history of the United States Army Medical Department in World War II.

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Depression, Smoking, and Ego-Centric Social Network Characteristics in Ohio Appalachian Women. This article describes the contact investigations performed by a county TB program in one year to flunil 10 mg green capsules from india illustrate the effort involved.

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in patients with hyperacute posterior circulation ischemic strokes, the clidets gel uson lesions assessed by dWi were associated with the clinical outcome, regardless of the initial neurological status. Prevention of wound infection in cardiac surgery: how much is topical use of antibiotics justified?

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Maternal characteristics and obstetrical complications impact neonatal outcomes in Indonesia: a prospective study. The affected patients in this kindred display a clinically distinct senexon liquid 8 8mg/2mg myopathy, with selective involvement of posterior lower and anterior upper limb muscles. There are evidences that WRKYs are involved in the resistance of some soybean genotypes against that fungus. Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549.

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